Unlock Your Unique Migraine-related Genetics

Migraine symptoms can take many forms, and there are many migraine management approaches. Knowing your genetics may help your healthcare provider find the right management option sooner.

Many forms of migraines are strongly influenced by genetics. Not only is it common for migraines to run in families, but studies have shown that certain genetic variations can cause certain types of migraines or indicate responsiveness to certain management options. Because of this, Avantra Genetics designed its Migraine Panel to provide healthcare providers with genetic information that can be used to identify the best management option. This is a great improvement over the typical trial-and-error approach, which can be time-consuming, expensive, and frustrating, considering the sizable list of migraine management options that are available.

Migraine Management Options

Supplements

CoQ-10 (Coenzyme Q-10)
Riboflavin (Vitamin B2)
5-HTP (5-Hydroxytryptophan)
Magnesium
Feverfew (Tanacetum parthenium)
Ginger
L-5MTHF (L-Methylfolate)

Lifestyle Management

Gluten-free diet
Ketogenic diet
Caffeine, alcohol, and MSG avoidance
Trigger identification and avoidance

Acute Medications

Analgesics / NSAIDs
Anti-migraine medications
Anti-nausea medications

Preventative Medications

Beta-blockers
Anti-serotonergic medications (SSRIs)
Tricyclic antidepressants (TCAs)
Anti-convulsants (AEDs)
Calcium channel blockers

Migraine Panel Details

The Avantra Genetics Migraine Panel is a novel genetic information service that provides several types of clinical data to your healthcare professional to evaluate. Foremost, the panel looks at genes associated with disorders that feature migraine pain, including coenzyme Q10 deficiency, mitochondrial DNA depletion syndrome, advanced sleep-phase syndrome, dystonia, and others. In addition, the panel also looks at major biochemical pathways and receptors that can play a role in a patient’s symptoms.

In all, we perform full-gene sequencing for 49 migraine-related genes, as well as looking at another 86 single locations (SNVs) related to migraines, plus another 85 single locations (SNPs) related to general wellness. The Avantra Genetics Migraine Panel is performed using the latest next-generation DNA sequencing technology in our CAP/CLIA certified laboratory.

Gene List

Disease-related Full Gene Sequencing List: ATP1A2, ATP1A3, CACNA1A, CACNA1S, COQ2, COQ4, COQ6, COQ7, COQ8A, CSNK1D, GABBR2, GABRA1, GABRA2, GABRA3, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG2, GABRQ, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRINA, HTR1A, HTR2A, HTR3A, KCNK18, MAGT1, MR1, MTHFR, NOTCH3, PDSS1, PDSS2, POLG, PRRT2, SCN10A, SCN11A, SCN1A, SCN9A, SLC2A1, SLC52A1, SLC6A4, TRAP1

Disease-related SNV List: 1p31.1a, ACVRL1+, ARMS2–HTRA1, ASTN2+, c7orf10+, CACNA1A, CARF, CFDP1, EDNRA, ENG+, ESR1+, FHL5, FHL5–UFL1+, GRIA1+, GRIA3, HCRTR2, HCTR1+, HEY2–NCOA7, HPSE2, IGSF9B, KCNK18+, KCNN3, LRP1, LRP1–STAT6– SDR9C7, MEF2D+, MPPED2, MRVI1, MTDH, MTHFR+, NBEA, ADAMTSL4–ECM1~, CCM2L–HCK~, DOCK4–IMMP2L~, FGF6~, GJA1~, GPR149~, ITPK1~, JAG1~, MED14–USP9X~, NOTCH4~, REST–SPINK2~, TGFBR2~, TSPAN2–NGF~, WSCD1–NLRP1~, ZCCHC14~, NOS3, NRP1, NSDHL, PHACTR1+, PLCE1, PRDM16+, RNF213, RYR2+, SLC24A3, SLC6A4, STX1A+, TGFBR2, TNF, TRPM8, TRPM8–HJURP+, YAP1

General Wellness SNP List: AANT, ACAT1, ACE, ADM, AHCY+, BDNF, BHMT+, BTD, C5, CBS+, COMT+, CoQ2, CoQ3, COX5A, COX6C, CYP27A1, CYP27B1, DHFR, ENPP1, GSS, GSTM1, GSTP+, IGF1, IL10, IL23R, IL6, IL6R, KCNJ11, MAOA, MAOB, MAT1A, MAT2B, MTHFR+, MTR, MTRR+, NLRP6, NOS, NOS3, PDHA1, PDHB, PEMT, PNMT, PTPN22, PTS, QDPR, SHMT1+, SIRT1, SLC19A1, SLC22A5, SLC25A15, SLC25A32, SLC2A1, SOD2, SULT1A3, SUOX+, TGFB1+, TNF-alpha+, TRAF1, TRAP1, USF1, VDR+

 

Note: +:multiple variants sequenced for this gene, ~:intronic location near this gene

Ready to Get Started?

To order the Avantra Genetics Migraine Panel, a healthcare professional (HCP) must complete and sign the Service Requisition Form. HCPs can complete the online form and directly submit to Avantra Genetics or print and fax the paper form. Patients can print the paper form to bring to their next HCP appointment or share the link to the online form with their HCP. Once we have received the completed form, we will contact the patient for payment and send them a Sample Collection Kit.

Frequently Asked Questions

Why is a healthcare professional's signature needed to order?

Avantra Genetics genetic services provide genetic information that is best reviewed by a healthcare professional (HCP). Avantra Genetics panels contain specific information about genetic variants as well as links to publicly available genetic references, that may provide additional information to the HCP which they can choose to incorporate to make informed treatment decisions for their patients.

How do I submit a sample?

After we receive an order for an Avantra Genetics panel, we will mail a saliva collection kit to the patient at the address provided on the Service Requisition Form. This kit includes instructions for collecting, labeling, and mailing the sample to our laboratory.

How does Avantra collect payment?

We will send instructions for completing online payment to the patient’s email address provided on the Service Requisition Form. We accept all major credit cards as well as PayPal.

Please note that we will not process any samples until payment has been received.

Who will receive the results?

Results are delivered to the healthcare professional who ordered the service in order to provide them with the opportunity to discuss the results and any follow-up testing with the patient.